The US response to the crisis, to be formally unveiled later by President Barack Obama, includes plans to build 17 treatment centers, train thousands of healthcare workers and establish a military control center for coordination, US officials told reporters.
"The goal here is to search American expertise, including our military, logistics and command and control expertise, to try and control this outbreak at its source in west Africa," Lisa Monaco, Obama's White House counter-terrorism adviser, told MSNBC television on Tuesday ahead of the announcement.
The World Health Organization (WHO) has said it needs foreign medical teams with 500-600 experts as well as at least 10,000 local health workers. The figures may rise if the number of cases increases, as is widely expected.
So far Cuba and China have said they will send medical staff to Sierra Leone. Cuba will deploy 165 people in October while China is sending a mobile laboratory with 59 staff to speed up testing for the disease. It already has 115 staff and a Chinese-funded hospital there.
But Liberia is where the disease appears to be running amok. The WHO has not issued any estimate of cases or deaths in the country since Sept. 5 and its director-general, Margaret Chan, has said there was not a single bed available for Ebola patients there.
Liberia, a nation founded by descendants of freed American slaves, appealed for US help last week.
"We are honestly at a loss as to how a single, private NGO is providing the bulk of isolation units and beds," MSF's international president, Joanne Liu, said in a speech to the United Nations in Geneva, adding that the charity was having to turn away sick people in Monrovia, the capital of Liberia.
"Highly infectious people are forced to return home, only to infect others and continue the spread of this deadly virus. All for a lack of international response," she said.
Obama, who has called the epidemic a national security crisis, has faced criticism for not doing more to stem the outbreak. The WHO said last week Ebola had killed more than 2,400 people out of 4,784 cases in west Africa.
U.S. officials stressed it was very unlikely the Ebola crisis could come to the United States. Measures were being taken to screen passengers flying out of the region, they said, and protocols were in place to isolate and treat anyone who arrived in the United States showing symptoms of the disease.
The president will visit the US Centers for Disease Control and Prevention in Atlanta on Tuesday to show his commitment. The stepped-up effort he will announce includes 3,000 military troops and a joint forces command center in Monrovia to coordinate efforts with the US government and other international partners.
The plan will "ensure that the entire international response effort is more effective and helps to ... turn the tide in this crisis," a senior administration official told reporters on Monday, ahead of the president's trip.
"The significant expansion that the president will detail ... really represents ... areas where the US military will bring unique capabilities that we believe will improve the effectiveness of the entire global response," he said.
The treatment centers will have 100 beds each and be built as soon as possible, another official said.
The US plan also focuses on training. A site will be established where military medical personnel will teach some 500 healthcare workers per week for six months or longer how to provide care to Ebola patients, officials said.
The Obama administration has requested an additional $88 million from Congress to fight Ebola, including $58 million to speed production of Mapp Biopharmaceutical Inc's experimental antiviral drug ZMapp and two Ebola vaccine candidates.
Officials said the US Department of Defense had sought to reallocate $500 million in funds from fiscal 2014 to help cover the costs of the humanitarian mission.
The US Agency for International Development will also support a program to distribute protection kits with sanitizers and medical supplies to 400,000 vulnerable households in Liberia.